Response of plasma IL-6 and its soluble receptors during submaximal exercise to fatigue in sedentary middle-aged men |
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| Authors: | S R Gray M Robinson M A Nimmo |
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| Institution: | (1) Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, Glasgow, UK;(2) Present address: School of Sport & Exercise Sciences, Loughborough University, Ashby Road, Loughborough, Leicestershire, LE11 3TU, UK;(3) Present address: Department of Sport and Exercise Science, University of Bath, Bath, UK |
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| Abstract: | The pleiotropic cytokine interleukin-6 (IL-6) has been demonstrated to increase during exercise. Little is known regarding
the response of the soluble IL-6 receptors (sIL-6R and sgp130) during such exercise. The aim of the current study was to investigate
the response of plasma IL-6, sIL-6R and sgp130 during fatiguing submaximal exercise in humans. Twelve participants underwent
an incremental exercise test to exhaustion and one week later performed a submaximal exercise bout (96 ± 6% lactate threshold)
to volitional exhaustion. Blood samples taken at rest and immediately post exercise were analyzed for IL-6, sIL-6R and sgp130.
IL-6 increased (P < 0.01) by 8.4 ± 8.9 pg ml−1 (75.7%) during the exercise period. sIL-6R and sgp130 also increased (P < 0.05) by 2.7 ± 3.9 ng ml−1 (9.6%) and 37.7 ± 55.6 ng ml−1 (9.6%), respectively. The current study is the first investigation to demonstrate that alongside IL-6, acute exercise stress
results in an increase in both sIL-6R and sgp130. |
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| Keywords: | Exercise stress Interleukin-6 Receptors Fatigue |
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