Synthesis, DNA binding and cleavage activities of the copper (II) complexes of estrogen-macrocyclic polyamine conjugates |
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Authors: | Yang Xin-Bin Feng Jie Zhang Ji Zhang Zhong-Wei Lin Hong-Hui Zhou Li-Hong Yu Xiao-Qi |
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Affiliation: | Department of Chemistry, Key Laboratory of Green Chemistry and Technology (Ministry of Education), Sichuan University, No. 29, Wangjiang Road, Chengdu, Sichuan 610064, PR China. |
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Abstract: | A series of the copper (II) complexes 5a-d of estrogen-macrocyclic polyamine conjugates were synthesized and characterized. The interactions of complexes 5a-d with DNA were studied by fluorescence spectroscopy and gel electrophoresis under physiological conditions. The results indicate that the conjugated estrogens have increased the cleavage efficiency of Cu[cyclen](2+) while the conjugates display poor binding affinities. The functional groups of D-ring of estrogens may play a key role in deciding binding and cleavage extent of the complexes to DNA. |
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