Synthesis and anti-cancer activity of benzothiazole containing phthalimide on human carcinoma cell lines |
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Authors: | Kok Stanton Hon Lung Gambari Roberto Chui Chung Hin Yuen Marcus Chun Wah Lin Eva Wong Raymond Siu Ming Lau Fung Yi Cheng Gregory Yin Ming Lam Wing Sze Chan Sau Hing Lam Kim Hung Cheng Chor Hing Lai Paul Bo Shan Yu Michael Wing Yiu Cheung Filly Tang Johnny Cheuk On Chan Albert Sun Chi |
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Institution: | Lo Ka Chung Centre for Natural Anti-cancer Drug Development (Laboratory B), Hong Kong Polytechnic University, Yuk Choi Road, Hung Hom, Kowloon, Hong Kong, China. |
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Abstract: | Phthalic anhydride is a highly toxic substance, facing, however, the problem of hydrolysis. In fact, it is rapidly hydrolyzed in aqueous medium, generating phthalic acid as the final product, which is almost harmless to viable cells. Here we describe the 'one pot' condensation reaction for the synthesis of phthalic imide derivative (benzothiazole containing phthalimide), exhibiting in vitro cytotoxic potential on human cancer cell lines. We further demonstrated that both caspase-dependent and -independent pathways are involved in our novel benzothiazole containing phthalimide induced apoptosis on cancer cells. |
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