Capturing pluripotency |
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| Authors: | Silva Jose Smith Austin |
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| Institution: | Wellcome Trust Centre for Stem Cell Research and Department of Biochemistry, University of Cambridge, Cambridge CB2 1QR, UK. |
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| Abstract: | In this Essay, we argue that pluripotent epiblast founder cells in the embryo and embryonic stem (ES) cells in culture represent the ground state for a mammalian cell, signified by freedom from developmental specification or epigenetic restriction and capacity for autonomous self-replication. We speculate that cell-to-cell variation may be integral to the ES cell condition, safe-guarding self-renewal while continually presenting opportunities for lineage specification. |
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