Removal of Anti-complementary Material and Australia Antigen from Immunoglobulin |
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| Authors: | A Polson |
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| Institution: | M.R.C. and U.C.T. Virus Research Unit, Medical School , Observatory, Cape Town, Republic of South Africa |
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| Abstract: | Inmunoglobulin isolated from human sera, be it by the cryo-alcohol, rivanol, multi membrane electrodecantation or polyethylene glycol process, alvays contains denatured material. This may result from the influence either singly or in combination, of acme of the follwing factors: -
inefficiency of the purification procedure; -
surface denaturation; -
imperfect freeze-drying of the final product; and -
factors yet unknown vhich cause alteration in the immoglobulins or other protein components not ellminated by the purification procedures. |
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