Multiple Activities Of DNA Polymerase from Visna Virus |
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| Authors: | F H Lin M Genovese H Thormar |
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| Institution: | New York Stats Institute for Research in Mental Retardation Staten , Island, New York, 10314 |
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| Abstract: | Daoxyribonucleic acid (DNA) polymerase Isolated from visne virus has been separated into three enzymatically active polypeptides by column chromatography on DEAE-cellulose. They are designated polymerase I, II and III according to the order of elutlon from the column. The three enzymes are different in their pH optimum, sensitivity to N-ethylmaleimide, rate of catalytic reaction, and preference of template. The molecular weights were estimated to be 125, 000 for polymerase I and 18, 000 for II. |
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