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A Simple Preparation of N-Phosphorylated Lysine and Arginine |
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| Authors: | James M Fujitaki Anton W Steiner Scott E Nichols Eric R Helander Y C Lin Roberts A Smith |
| Institution: | 1. Department of Chemistry and Molecular Biology Institute , University of California , Los Angeles, California, 90024;2. Department of Chemistry , National Taiwan University , Taipei, Taiwan, Republic of China |
| Abstract: | An improved specific synthesis of N-ε-phospholysine is described. Phosphorylation under basic conditions of the copper chelate of L-lysine with phosphorus oxychloride and subsequent removal of the copper ion affords N-ε-phospholysine as the sole phosphorylated product. Similar treatment of L-arginine yields N-ω-phosphoarginine as the sole product which is identical to that produced enzymatically. |
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