Cholecystokinin and thermoregulation--a minireview. |
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Authors: | Z Szelényi |
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Institution: | Department of Pathophysiology, Faculty of Medicine, University of Pécs, 7624 Pécs, Hungary. szelenyi@apacs.pote.hu |
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Abstract: | Thermoregulatory effects of cholecystokinin (CCK) peptides are reviewed with special emphasis on two types of responses, that is hypothermia or hyperthermia. In rodents exposed to cold a dose-dependent hypothermia has been observed on peripheral injection of CCK probably acting on CCKA receptors. Central microinjection of CCK in rats induced a thermogenic response that could be attenuated by CCKB receptor antagonists, but some authors observed a hypothermia. It is suggested that neuronal CCK may have a specific role in the development of hyperthermia, and endogenous CCK-ergic mechanisms could contribute to the mediation of fever. Possible connections between thermoregulatory and other autonomic functional changes induced by CCK are discussed. |
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