The effect of macromolecular conjugates of daunorubicin on nuclear ultrastructure in Trypanosoma brucei rhodesiense |
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Authors: | L Golightly J E Brown J B Mitchell J R Brown |
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Affiliation: | Tropical Diseases Chemotherapy Research Unit, Sunderland Polytechnic, Sunderland SR1 3SD U.K. |
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Abstract: | The effects of free and conjugated daunorubicin on T.b. rhodesiense in vitro are described. Free drug caused nucleolar lesions ranging from segregation to complete fragmentation. At equimolar concentrations a soluble bovine serum albumin conjugate with a stable succinyl linkage (D-BSAS) produced no ultrastructural lesions whereas a conjugate with a labile glutaraldehyde linkage (D-BSAG) and a conjugate linked to large agarose beads (D-ag) produced similar though less severe lesions than free drug. Polyisobutylcyanoacrylate nanoparticles caused trypanosomal lysis both with (D-PICA) and without adsorbed daunorubicin. |
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