Changes in Chromatin Organization during Early Development and Carcinogenesis |
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| Authors: | Hair A. Vassetzky Y. Razin S. V. |
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| Affiliation: | (1) Gene Expression Group, School of Biological Sciences, The University of Manchester, Stopford Building, Oxford Rd, Manchester, M13 9PT;(2) Institut de Génétique Humaine, CNRS UPR1142, 141, rue de la Cardonille, 34396 Montpellier Cedex 5, France;(3) Russian Academy of Sciences, Kol'tsov Institute of Developmental Biology, ul. Vavilova 26, Moscow, 119991, Russia;(4) Russian Academy of Sciences, Institute of Gene Biology, ul. Vavilova 34/5, Moscow, 117334, Russia |
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| Abstract: | Similar changes in chromatin organization take place during development and carcinogenesis. The size of chromatin loop domains fixed on the nuclear skeleton (matrix) increased from 20 to approximately 200 kb. These changes are accompanied by an increased size of replicons and altered specificity of loop attachment to the nuclear matrix. During carcinogenesis, inverse changes in the chromatin structure are observed, neoplastic cells are dedifferentiated and return to the initial state. In this review, we consider new experimental data on organization of the DFNA loops and nuclear matrix in embryogenesis and carcinogenesis. |
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| Keywords: | nuclear matrix DNA loop domains development cancer chromatin |
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