Eotaxin-1在浆液性卵巢癌组织中的表达及临床意义研究

目的:研究嗜酸性粒细胞趋化因子1(Eotaxin-1)在浆液性卵巢癌组织中的表达及临床病理意义。方法:收集2013年4月至2014年5月于我院妇产科手术切除的60例浆液性卵巢癌及对应癌旁组织,采用免疫组织化学染色检测Eotaxin-1表达,分析Eotaxin-1蛋白与肿瘤临床病理资料之间的相关性。结果:浆液性卵巢癌组织中Eotaxin-1蛋白表达水平较对应癌旁组织显著升高(P0.05),浆液性卵巢癌组织中高表达Eotaxin-1蛋白与恶性组织病理分级、淋巴结转移及高TNM分期呈显著正相关(P0.05)。结论:Eotaxin-1蛋白在浆液性卵巢癌组织中表达上调,并与肿瘤恶性临床病理特征有关;Eotaxin-1可能成为浆液性卵巢癌早期诊断的重要标志物和生物靶向治疗的有效靶点之一,具有广阔的临床应用前景。

The Expression and Clinical Significance of Eotaxin-1 in Human Serous Ovarian Cancer

Objective:To investigate the expression and clinical significance of Eotaxin-1 in human serous ovarian cancer.Methods:Immunohistochemistry (IHC) was applied to detect the protein expression of Eotaxin-1 in erous ovarian cancer (n=60) in comparison to the corresponding tumor-adjacent normal tissues. Pearson chi-square test was used to analyze the relationship between the Eotaxin-1 expression and clinical features.Results:The protein expression level of Eotaxin-1 in serous ovarian cancer tissues was significantly higher than in adjacent normal tissues (P<0.05). The positive expression of Eotaxin-1 protein was also associated with malignant tissue pathologic grades, lymphatic metastasis and advanced TNMstage (P<0.05).Conclusion:The expression of Eotaxin-1 in serous ovarian cancer tissues was significantly higher than in tumor-adjacent normal tissues, and associated with tumor malignant clinicopathological features Eotaxin-1 may become a new diagnosed marker and effective therapeutic target.