“一枝好”育发液促进毛发生长及机制探讨

目的:考察利用新疆维吾尔族传统药物研制成的"一枝好"育发液促进毛发生长的效果,并探讨其可能的作用机制。方法:采用硫化钠溶液建立昆明小鼠化学性脱发实验模型,将30只昆明小鼠随机分为实验组、阳性对照组(章光101育发剂)、空白对照组,以毛发评分、毛长、毛重以及毛囊数为指标,考察小鼠新生毛发生长情况。对脱毛后21天的脱毛区皮肤毛长、毛重、毛囊数进行测量和统计分析。并利用MTT法初步探讨"一枝好"育发液对人脐静脉血管内皮细胞(HUVEC)增殖的影响。结果:实验组脱毛区体毛生长评分及毛长,与空白对照组差异显著,并且略高于阳性对照组。对小鼠毛重与毛囊数的统计结果显示,与空白对照组和阳性对照组相比,实验组均有显著性差异(P0.01,P0.001)。"一枝好"育发液能够促进人脐静脉血管内皮细胞(HUVEC)增殖。结论:利用新疆维吾尔族传统药物研制成的"一枝好"育发液,能够显著促进小鼠毛发生长,初步推断其作用机制与促进毛囊生长和促进血管内皮细胞增殖有关。

Research on the Promoting Effects of "Yizhihao" on Hair Growth in Mice

Objective:To study the effects of Xinjiang Uygur traditional Chinese herbal preparation "Yizhihao" on hair growth inmice, and to investigate its possible mechanism.Methods:Kun Ming mice were chosen as experimental animals. The 30 mice wererandomly divided into test group, normal control group and positive control group. The hair growth condition in 21 days was observed, aswell as the hair length and weight of each group. MTT assay was used to investigate the proliferation effects on human umbilical veinvascular endothelial cells (HUVECs) of the aqueous extract of "Yizhihao".Results:Compared with the normal control group, the hairlength, weight and the number of hair follicles showed great significant difference (P<0.01,P<0.001). Compared with that in the positivecontrol group, the hair weight was higher and the number of hair follicles was more in the test group. "Yizhihao" could promote thegrowth and proliferation of HUVECs significantly.Conclusion:Xinjiang Uygur traditional Chinese herbal formulation "Yizhihao" cansignificantly promote hair growth in mice and its possible mechanismis to promote the growth of hair follicles and HUVECs.