Influence of a dosing-time on toxicities induced by docetaxel,cisplatin and 5-fluorouracil in patients with oral squamous cell carcinoma; a cross-over pilot study |
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| Authors: | Yoshiyuki Tsuchiya Tadahide Noguchi Naruo Okada Jun-ichi Hayasaka Yoshinori Jinbu |
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| Institution: | 1. Department of Dentistry, Oral and Maxillofacial Surgery, Jichi Medical University, Tochigi, Japan;2. Oral and Maxillofacial Surgery, Tochigi Cancer Center, Tochigi, Japan |
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| Abstract: | Docetaxel, cisplatin plus fluorouracil (DCF) regimen is a useful chemotherapy, but is sometimes withdrawn due to severe adverse effects (AE). In this study, we examined whether the chronotherapy of DCF regimen could reduce the drugs-induced toxicities in clinical practice. Patients with oral squamous cell carcinoma were enrolled. Chemotherapy started at 10:30 (Morning-dosing) or 18:30 (Evening-dosing) for 5 days by a cross-over design. AE were assessed for 14 days after an initiation of each dosing. The grades of nausea, vomiting and neutropenia were smaller during Evening-dosing than during Morning-dosing. These data suggest that the chrono-chemotherapy might provide a merit for reducing the DCF regimen-related severe AE. |
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| Keywords: | Adverse effect chemotherapy chronotherapy clinical trial |
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