CD4~+CD25~+Treg细胞在类风湿关节炎中的研究进展

调节性T细胞(Tregs)是近年来发现的一群具有免疫调节作用的CD4+T细胞亚群,如Th3、Tr1细胞等。因其能够产生多种具有免疫抑制作用的细胞因子而发挥其免疫负调节作用,不但在维持机体自身耐受方面发挥重要作用,在预防自身免疫性疾病方面也占据重要位置。其中CD4+CD25+Treg因其具有独特的作用方式及功能特征,而被学者广泛关注。近年来,关于CD4+CD25+Treg在类风湿关节炎(rheumatoid arthritis,RA)发病机制中的作用以及在RA治疗方面的应用也越来越受到人们的关注,认为其数目减少或功能失调与RA发病密切相关。RA是一种以关节破坏为主要表现的慢性炎症性疾病,病理早期主要表现为毛细血管生成,滑膜增生,后期主要表现为炎性细胞浸润,血管翳形成,并出现关节软骨以及骨的破坏,最终导致关节畸形及功能障碍。本文现将CD4+CD25+Treg与RA的研究进展做一综述。

Research Progress ofCD4+CD25 + Regulatory T Cells in Rheumatoid Arthritis

Regulatory T cells (Tregs) are a subset of CD4+T cells with immune-regulatory function which were discovered in recent years, such as Th3 and Tr1 cells, the immunosuppressive effect can be exerted through prouducing a variety of immunosuppressivecytokines, which play an important role not only in maintaining the immune tolerance, but also in preventing autoimmune diseases.Among these Tregs, CD4+CD25+Tregs are widely concerned because of their unique mode of action and functional characteristics. Inrecent years, the effect of CD4+CD25+Tregs in the pathogenesis mechanism of RA and the use of CD4+CD25+Tregs in RA treatment hasreceived wide public attention from people. It is considered that their decrease in the number or dysfunction is closely related to thepathogenesis of RA. RA is characterized by progressive joint damage. Early stages of disease progression are defined by capillary formation, hyperplasia of the synovial membrane. Established RA exhibits cellular infiltration, pannus formation, cartilage degradation andbone erosion, and eventually induces the joint deformity and dysfunction. Here is a review of the research progress of CD4+CD25+Tregsin RA.