Cyclic AMP as an inducer of the cell differentiation of Trypanosoma cruzi |
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| Authors: | R Rangel-Aldao F Triana V Fernández G Comach T Abate R Montoreano |
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| Institution: | Centro de Investigaciones Biomédicas, Universidad de Carabobo, Venezuela. |
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| Abstract: | The addition to epimastigotes cultures of T. cruzi, of either cAMP, monobutyryl-cAMP, dibutyryl-cAMP, 8-Br-cAMP (at 2 mM each), or the cAMP-phosphodiesterase inhibitor, papaverine (0.2 mM), promoted the in vitro differentiation of these parasite forms into metacyclics. This effect of cAMP may also be exerted in vivo in the insect vector, since cAMP was detected in the urine and in the Malpighi secretion fluids of Rodnius prolixus. |
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