Purification of bone morphogenetic protein derived from bovine bone matrix |
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Authors: | K Bessho T Tagawa M Murata |
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Institution: | Department of Oral Surgery, Faculty of Medicine, Mie University, Japan. |
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Abstract: | Bone morphogenetic protein (BMP) was extracted from the bovine bone matrix and purified by liquid chromatography. The molecular weight of the BMP was 18 kDa by SDS-PAGE, and its pI value was 4.9. Amino acid analysis suggested that the BMP is a polypeptide containing 163 amino acids. In the present study, telopeptide-free type I collagen was used as a carrier of BMP. |
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