On the architecture of cell regulation networks |
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| Authors: | Yueheng Lan Igor Mezić |
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| Affiliation: | (1) Department of Physics, Tsinghua University, Beijing, 100084, China;(2) The Center for Control, Dynamical Systems and Computation, University of California, Santa Barbara, CA 93106, USA;(3) Department of Mechanical Engineering, University of California, Santa Barbara, CA 93106, USA |
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| Abstract: | Background With the rapid development of high-throughput experiments, detecting functional modules has become increasingly important in analyzing biological networks. However, the growing size and complexity of these networks preclude structural breaking in terms of simplest units. We propose a novel graph theoretic decomposition scheme combined with dynamics consideration for probing the architecture of complex biological networks. |
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