Aging impacts isolated lymphoid follicle fevelopment and function |
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Authors: | Keely G McDonald Matthew R Leach Conway Huang Caihong Wang and Rodney D Newberry |
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Institution: | (1) Department of Internal Medicine, Washington University School of Medicine, St. Louis, Missouri 63110, USA;(2) University of Texas Southwestern Medical School, Austin Texas, 78701, USA |
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Abstract: | Background Immunosenescence is the age-related decline and dysfunction of protective immunity leading to a marked increase in the risk
of infections, autoimmune disease, and cancer. The majority of studies have focused on immunosenescence in the systemic immune
system; information concerning the effect of aging on intestinal immunity is limited. Isolated lymphoid follicles (ILFs) are
newly appreciated dynamic intestinal lymphoid structures that arise from nascent lymphoid tissues, or cryptopatches (CP),
in response to local inflammatory stimuli. ILFs promote "homeostatic" responses including the production of antigen-specific
IgA, thus playing a key role in mucosal immune protection. ILF dysfunction with aging could contribute to immunosenescence
of the mucosal system, and accordingly we examined phenotypic and functional aspects of ILFs from young (2 month old) and
aged (2 year old) mice. |
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Keywords: | |
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