Characterization of a ranavirus inhibitor of the antiviral protein kinase PKR |
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| Authors: | Stefan Rothenburg V Gregory Chinchar Thomas E Dever |
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| Affiliation: | (1) Laboratory of Gene Regulation and Development, NICHD, National Institutes of Health, Bethesda, MD 20892, USA;(2) Division of Biology, Kansas State University, Manhattan, KS 66506, USA;(3) Department of Microbiology, University of Mississippi Medical Center, Jackson, MS 39216, USA |
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| Abstract: | Background Ranaviruses (family Iridoviridae) are important pathogens of lower vertebrates. However, little is known about how they circumvent the immune response of their hosts. Many ranaviruses contain a predicted protein, designated vIF2α, which shows homology with the eukaryotic translation initiation factor 2α. In analogy to distantly related proteins found in poxviruses vIF2α might act as an inhibitor of the antiviral protein kinase PKR. |
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