Formation of human prostate tissue from embryonic stem cells |
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| Authors: | Taylor Renea A Cowin Prue A Cunha Gerald R Pera Martin Trounson Alan O Pedersen John Risbridger Gail P |
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| Affiliation: | Centre for Urological Research, Monash Institute of Medical Research, Monash University, 27-31 Wright Street, Clayton, Victoria, Australia 3168. |
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| Abstract: | Rodent models and immortalized or genetically modified cell lines are frequently used-but have limited utility-for studying human prostate development and maturation. Using rodent mesenchyme to establish reciprocal mesenchymal-epithelial cell interactions with human embryonic stem cells (hESCs), we generated human prostate tissue expressing prostate-specific antigen (PSA) within 8-12 weeks. This human prostate model shows species-conserved signalling mechanisms that could extend to integumental, gastrointestinal and genital tissues. |
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