Protection of cattle against bovine leukemia virus (BLV) infection could be attained by DNA vaccination |
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| Authors: | Brillowska A Dabrowski S Ru?ka J Kubi? P Buza?a E Kur J |
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| Institution: | Technical University of Gdańsk, Department of Microbiology, Poland. |
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| Abstract: | The bovine leukemia virus (BLV) envelope gene encoding extracellular glycoprotein gp51 and transmembrane glycoprotein gp30 was cloned into a vehicle expression vector under the human cytomegalovirus (CMV) intermediate early promoter. The intramuscular injection of this plasmid vector generated a cellular immune response. Seven out of ten cows vaccinated with the DNA construct resisted a drastic challenge (500 BLV-infected lymphocytes as an infectious dose). |
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