T3JAM, a novel protein that specifically interacts with TRAF3 and promotes the activation of JNK(1) |
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Authors: | Dadgostar Hajir Doyle Sean E Shahangian Arash Garcia Daniel E Cheng Genhong |
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Affiliation: | Medical Scientist Training Program, University of California Los Angeles, Los Angeles, CA 90095, USA. |
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Abstract: | Previous studies suggest that localization of tumor necrosis factor receptor (TNFR)-associated factor (TRAF) family members is important for regulating their signal transduction. During a screen for TRAF3-associated proteins that potentially alter TRAF3 subcellular localization and enable signal transduction, we identified a novel protein, T3JAM (TRAF3-interacting Jun N-terminal kinase (JNK)-activating modulator). This protein associates specifically with TRAF3 but not other TRAF family members. Coexpression of T3JAM with TRAF3 recruits TRAF3 to the detergent-insoluble fraction. More importantly, T3JAM and TRAF3 synergistically activate JNK but not nuclear factor (NF)-kappaB. Our studies indicate that T3JAM may function as an adapter molecule that specifically regulates TRAF3-mediated JNK activation. |
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Keywords: | Tumor necrosis factor receptor-associated factor 3 Tumor necrosis factor receptor Jun N-terminal kinase Nuclear factor κB Subcellular localization Signal transduction |
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