Mitochondria,spermatogenesis and male infertility |
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| Authors: | Singh Rajender Pandey Rahul Abbas Ali Mahdi |
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| Affiliation: | 1. Division of Endocrinology, Central Drug Research Institute, Lucknow, UP, India;2. Translational Health Science Unit, Research Cell, Chhatrapati Sahuji Maharaj Medical University, Lucknow, UP, India;3. Department of Biochemistry, Chhatrapati Sahuji Maharaj Medical University, Lucknow, UP, India;1. Department of Applied Chemistry, Birla Institute of Technology, Mesra, Ranchi 835215, Jharkhand, India;2. Department of Bio-Engineering, Birla Institute of Technology, Mesra, Ranchi 835215, Jharkhand, India;1. Reproductive Medicine & Medical Cytogenetics, Centre of Obstetrics and Gynecology, Regional University Hospital and School of Medicine. Picardie University Jules Verne, Amiens, France;2. Fertilys Inc., Laval, Québec QC, Canada;3. Andrology unit, ForteBio Laboratory, Dax, France;4. IVF & Genetics Laboratory, LaboMac, Clinique des Iris, Casablanca, Morocco;1. Centre for Bioinformatics, Pondicherry University, Puducherry, India;2. KIIT University, Bhubaneswar, Odisha, India |
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| Abstract: | Mitochondria and its role in male reproduction has remained an enigma since long. Similarly, etiology of male infertility in a large percentage of individuals, mainly primary infertility, has evaded concrete conclusions. Oxidative metabolism, energy production and free radical generation are the principal biological reactions occurring inside mitochondria. In addition to the above, mitochondria participates in an important process of apoptosis. Mitochondrial causes of infertility have triggered interest because of its presence in the tail of sperm and immense need of energy for sperm motility. Several studies on mitochondria have strongly suggested its role in fertility, some of which support mitochondrial role presenting numerous hypotheses, whereas others deny its very existence as a causative factor. We have, in the present review of existing literature, covered the role of mitochondria right from spermatogenesis to male infertility. |
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