Papel de pituitary tumour-transforming gene (PTTG) en los adenomas hipofisarios |
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| Authors: | Ruth Sánchez-Ortiga Laura Sánchez Tejada Gloria Peiró Cabrera Oscar Moreno-Pérez Nieves Arias Mendoza F Ignacio Aranda López Antonio Picó Alfonso |
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| Institution: | 1. Sección de Endocrinología y Nutrición, Hospital General Universitario de Alicante, Alicante, España;2. Servicio de Anatomía Patológica, Hospital General Universitario de Alicante, Alicante, España;3. Sección de Endocrinología y Nutrición, Hospital de Elda, Alicante, España;1. Infection and Cancer Group, School of Medicine and Corporación Académica para el Estudio de Patologías Tropicales, Universidad de Antioquia, UdeA, Calle 70 No 52-21, Medellín, Colombia;2. Genética Molecular, Universidad de Antioquia, UdeA, Calle 70 No 52-21, Medellín, Colombia;3. Universidad Cooperativa de Colombia, Carrera 42 No 49-95, Medellín, Colombia;4. Instituto de Cancerología Las Américas, Carrera 70 No 1-35, Torre 5, Medellín, Colombia;5. Department of Gynecology and Obstetrics, School of Medicine, Universidad de Antioquia, UdeA, Calle 70 No 52-52, Medellín, Colombia;6. Escuela de Microbiología, Universidad de Antioquia UdeA, Calle 70 No 52-21, Medellín, Colombia;1. Institut National de la Santé et de la Recherche Médicale (INSERM) U981, Institut de cancérologie Gustave Roussy, Villejuif, F-94800, France;2. Department of Medical Oncology, S. Andrea Hospital, University of Rome « Sapienza », Rome, Italy;3. Department of Medical Oncology, Institut de cancérologie Gustave Roussy, Villejuif, F-94800, France;1. MD (Young researcher - U of A, Infection and Cancer Group - Medical School - University of Antioquia, UdeA, Medellin, Colombia).;2. DDS, MSC, Maxillofacial surgeon (Assistant Professor, Dentistry School - University of Antioquia and Las Vegas Clinic, Medellin, Colombia).;3. BSc, MSc (PhD student, University of Alicante, Alicante, Spain).;4. Ing., BSc statistician (PhD student of epidemiology, Infection and Cancer Group - University of Antioquia, UdeA, Medellin, Colombia).;5. MD, Pathologist (Assistant professor, Department of Pathology - Medical School - University of Antioquia, Medellin, Colombia).;6. DDS; MSc (Associate professor - School of Dentistry - University of Antioquia, Medellin, Colombia).;7. MSc.; Ph.D (Associate Professor, Coordinator of the Infection and Cancer Group, University of Antioquia, UdeA, Medellin, Colombia). Infection and Cancer Group & Department of Pathology - School of Medicine; School of Dentistry; University of Antioquia, Medellin, Colombia.;1. Center for Molecular Medicine, Xiangya Hospital, Central South University, 87 Xiangya Road, 410008, Changsha, Hunan, China;2. Department of Pathology, Nagoya University Graduate School of Medicine, Nagoya, 466-8550, Japan;3. Key Laboratory of Molecular Radiation Oncology Hunan Province, 410008, Changsha, Hunan;1. Department of Analytical Chemistry, Nutrition and Food Sciences, University of Alicante, PO Box 99, 03080 Alicante, Spain;2. Department of Biotechnology, University of Alicante, PO Box 99, 03080 Alicante, Spain |
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| Abstract: | The pathogenesis of pituitary tumours is far to be understood. Pituitary transforming tumour gene (PTTG), a gen that induces aneuploidy, genetic instability, cellular proliferation and to stimulate angiogenesis, has been involved in neoplasic transformation and shown overexpressed in many neoplasm as lung, breast, endometrium, thyroid and colon malignant tumours. On the other hand, PTTG has been inconsistently studied in pituitary tumours. The majority of studies have been performed in animals and there is a great variability in the methods used in its determination. The goal of this review is to resume the role of PTTG in tumourogenesis and critically to revise the studies published in humans in order to advance in the knowledge of the pathogenesis of pituitary adenomas and to find clinical useful predictors of the behavior of these tumours. |
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