Maternal diabetes and oocyte quality |
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| Authors: | Qiang Wang Kelle H Moley |
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| Institution: | 1. Department of Anesthesiology, University of California, Los Angeles, CA 90095, USA;2. Division of Plant Biology, Bose Institute, Kolkata 700054, India;3. Department of Physiology, University of California, Los Angeles, CA 90095, USA;4. Department of Brain Research Institute, University of California, Los Angeles, CA 90095, USA;5. Department of Cardiovascular Research Laboratory, University of California, Los Angeles, CA 90095, USA;6. Department of Molecular and Medical Pharmacology, University of California, Los Angeles, CA 90095, USA |
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| Abstract: | Maternal diabetes has been demonstrated to adversely affect preimplantation embryo development and pregnancy outcomes. Emerging evidence has implicated that these effects are associated with compromised oocyte competence. Several developmental defects during oocyte maturation in diabetic mice have been reported over past decades. Most recently, we further identified the structural, spatial and metabolic dysfunction of mitochondria in oocytes from diabetic mice, suggesting the impaired oocyte quality. These defects in the oocyte may be maternally transmitted to the embryo and then manifested later as developmental abnormalities in preimplantation embryo, congenital malformations, and even metabolic disease in the offspring. In this paper, we briefly review the effects of maternal diabetes on oocyte quality, with a particular emphasis on the mitochondrial dysfunction. The possible connection between dysfunctional oocyte mitochondria and reproductive failure of diabetic females, and the mechanism(s) by which maternal diabetes exerts its effects on the oocyte are also discussed. |
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