A PIAS-ed view of DNA double strand break repair focuses on SUMO |
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| Authors: | Anastasia Zlatanou Grant S Stewart |
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| Institution: | 3. From the Laboratories for Reproductive Biology, Department of Pediatrics, University of North Carolina, Chapel Hill, North Carolina 27599;4. Department of Cell Biology and Physiology, University of North Carolina, Chapel Hill, North Carolina 27599;6. Lineberger Comprehensive Cancer Center, and University of North Carolina, Chapel Hill, North Carolina 27599;12. Department of Biochemistry and Biophysics, University of North Carolina, Chapel Hill, North Carolina 27599;5. Department of Urology, Roswell Park Cancer Institute, Buffalo, New York 14263;1. Department of Physiology, Development and Neuroscience and;2. British Heart Foundation Centre of Research Excellence, University of Cambridge, Cambridge, United Kingdom;;3. Department of Clinical Sciences, Lund University, Lund, Sweden; and;4. Department of Cell and Molecular Biology, Karolinska Institutet, Stockholm, Sweden;1. Department of Hematopathology, The University of Texas MD Anderson Cancer Center, Houston, TX;2. Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX;3. Graduate School of Biomedical Sciences, The University of Texas MD Anderson Cancer Center, Houston, TX;1. Department of Internal Medicine, School of Medicine, Chungnam National University, Daejeon, Republic of Korea;2. School of Pharmacy, Chungnam National University, Daejeon, Republic of Korea;3. Daejeon Regional Cancer Center, Daejeon, Republic of Korea;1. Department of Pulmonary Medicine, Affiliated Hospital of Jiangsu University, Zhenjiang 212001, China;2. Department of Thoracic Surgery, Affiliated Hospital of Jiangsu University, Zhenjiang 212001, China;3. Institute of Medical Science, Jiangsu University, Zhenjiang 212013, China |
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| Abstract: | Through the action of multiple sensors, mediators, and effectors, the DNA damage response (DDR) orchestrates the repair of DNA damage to ensure maintenance of genomic integrity. Recently, in addition to phosphorylation, other post-translational modifications such as ubiquitylation and SUMOylation have emerged as important regulators of the DDR network. Two recent papers highlight the importance of SUMO modifications of proteins that execute the response to DNA damage. |
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