| 神经降压素对刺激下丘脑减压区所致减压反应的影响 |
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| 引用本文： | 陈家津,陈蕾.神经降压素对刺激下丘脑减压区所致减压反应的影响[J].动物学报,1994,40(3):281-286. |
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| 作者姓名： | 陈家津 陈蕾 |
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| 作者单位： | 青岛医学院生理学教研室!266021 |
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| 摘 要： | 大鼠下丘脑前部一侧减压区，采用直流方波或化学刺激、注射微量神经降压素及其抗血清和放射免疫分析等方法，探讨了神经降压素对刺激该减压区所致减压反应的影响。结果表明：（１）电或化学刺激该减压区，可出现同其它哺乳动物相似的减压反应；（２）该减压区注射微量神经降压素，可使电刺激该减压区所致的减压反应明显增强；反之，注射抗神经降压素血清，该减压反应明显抑制；（３）电刺激该减压区，可使下丘脑和血浆中的神经降压素免疫活性物含量明显增高。结果提示，神经降压素可能参与电刺激该减压区所致的减压反应过程。
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| 关 键 词： | 下丘脑减压区 神经降压素 减压反应 |
EFFECT OF NEUROTENSIN ON THE HYPOTENSIVE RESPONSE ELICITED BY STIMULATION OF ANTERIOR HYPOTHALAMIC DEPRESSIVE AREA IN RAT |
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| CHEN JIA-JIN,CHEN LEI,CUI XIANG-DONG,XU LUO.EFFECT OF NEUROTENSIN ON THE HYPOTENSIVE RESPONSE ELICITED BY STIMULATION OF ANTERIOR HYPOTHALAMIC DEPRESSIVE AREA IN RAT[J].Acta Zoologica Sinica,1994,40(3):281-286. |
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| Authors: | CHEN JIA-JIN CHEN LEI CUI XIANG-DONG XU LUO |
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| Abstract: | The effects of intrahypothalamus injection of neurotensin (NT) on the hypotensive response elicited by stimulation of anterior hypothalamic depressive area in rat were investigated by means of microinjection and radioimmunoassay. The results indicated: (1) The hypotensive response elicited by electric and chemical stimulation of anterior hypothalamic depressive area in rat was similar to that in other mamlian animals. (2) The hypotensive response was enhanced by microinjection of NT into depressive area of anterior hypothalamus and attenuated by microinjection of anti-NT into aforesaid area. (3) The contents of NT in hypothalamus and plasma increased by stimulation of anterior hypothalamic depressive area. These results suggest that NT may involved in the hypotensive response caused by stimulation the anterior hypothalamic depressive area in rat. |
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| Keywords: | Rats Hypothalamic depressive aewa Neurotensin Hypotensive response |
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