LH excretion during the ovulatory cycle and during therapy with various estrogen-gestagen combinations

Immunochemical determination of urinary LH was carried out in 7 normally ovulating women and in 25 women treated with various combined, sequential, and depot hormonal contraceptives. In ovulatory cycles without hormone treatment an LH peak was always observed at midcycle. During treatment with Ovosiston, OZN, and Quinestrol-norethisterone acetate, no LH peak was seen. In women receiving sequential preparations (mestranol-chlormadinone acetate, estrone cyanate-chlormadinone acetate), elevated LH levels were observed during estrogen medication. LH excretion was suppressed after administration of chlormadinone acetate. LH levels were also slightly elevated before and after medication with Quinestrol-chlormadinone acatate (1 pill per month).