Post-synaptic Inhibition in the Cuneate blocked by GABA Antagonist

PICROTOXIN has been shown to antagonize specifically the inhibitory action of λ-aminobutyric acid (GABA) as opposed to glycine (Gly) on cells of the cuneate nucleus, either spontaneously active or excited by peripheral stimulation¹. Bicucul-line also seems to be a specific antagonist of the depressant action of GABA in several regions of the mammalian nervous system², although probably not in others³.