Lipid peroxidation, iron mobilization and radical generation induced by alcohol |
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Authors: | S Shaw |
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Affiliation: | General Medical Research, VA Medical Center, Bronx, New York. |
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Abstract: | Increasing evidence points to a major role for free radicals in the pathogenesis of alcohol-induced liver injury. In vitro, free radicals may be generated during ethanol metabolism by the further metabolism of acetaldehyde by molybdenum-dependent oxidases such as xanthine oxidase. Ferritin iron mobilized by such free radicals may serve as catalytic iron. Increased stores of ferritin iron and induction of microsomal P-450 reductase activity are mechanisms by which chronic alcohol feeding may potentiate the acute effects of alcohol. |
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