Double-strand break generation under deoxyribonucleotide starvation in Escherichia coli |
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| Authors: | Guarino Estrella Salguero Israel Jiménez-Sánchez Alfonso Guzmán Elena C |
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| Affiliation: | Departamento de Bioquímica, Biología Molecular y Genética, Facultad de Ciencias, Universidad de Extremadura, 06080-Badajoz, Spain. |
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| Abstract: | Stalled replication forks produced by three different ways of depleting deoxynucleoside triphosphate showed different capacities to undergo "replication fork reversal." This reaction occurred at the stalled forks generated by hydroxyurea treatment, was impaired under thermal inactivation of ribonucleoside reductase, and did not take place under thymine starvation. |
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