Chrysin,a natural flavone,improves murine inflammatory bowel diseases |
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| Authors: | Eun Kyung Shin Hyuck-Se Kwon Yoon Hee Kim Hyun-Kyung Shin Jin-Kyung Kim |
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| Institution: | 1. Zanjan Pharmaceutical Nanotechnology Research Center, Zanjan University of Medical Sciences, Zanjan, Iran;2. Department of Pharmaceutical Biomaterials, School of Pharmacy, Zanjan University of Medical Sciences, Zanjan, Iran;3. Department of Medical Biotechnology and Nanotechnology, School of Medicine, Zanjan University of Medical Sciences, Zanjan, Iran;4. Department of Pharmaceutical Biotechnology, School of Pharmacy, Zanjan University of Medical Sciences, Zanjan, Iran;5. Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran;1. Departamento de Farmacia, Escuela Nacional de Ciencias Biológicas, Campus Zacatenco, Instituto Politécnico Nacional, Av. Wilfrido Massieu s/n Col. Zacatenco, CP 07730, Mexico, DF, Mexico;2. Department of Pharmacology, Faculty of Pharmacy, University of Seville, Profesor García González Street 2, 41012, Seville, Spain;1. Institute of Chemical Sciences, University of Peshawar, Peshawar, Pakistan;2. Department of Geology, University of Peshawar, Peshawar, Pakistan;3. HEJ Research Institute, Institute of Chemical and Biological Sciences, University of Karachi, Karachi, Pakistan;4. Department of Pharmacy, Abdul Wali Khan University of Mardan, Mardan, Pakistan;5. Department of Pharmacy, University of Peshawar, Peshawar, Pakistan;6. Department of Pharmacy, University of Salerno, Fisciano, Salerno, Italy;7. Department of Pharmacy, University of Naples, Federico II, Naples, Italy |
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| Abstract: | Chrysin (5,7-dihydroxyflavone) is a natural flavone commonly found in many plants. It has previously been shown to be an anti-tumor agent. In this study, we investigated whether chrysin could alleviate the symptoms of dextran sodium sulfate (DSS)-induced colitis in mice and whether chrysin has an inhibitory effect on nuclear factor (NF)-κB activation in vitro. A significant blunting of weight loss and clinical signs was observed in DSS-exposed, chrysin-treated mice when compared to vehicle-treated mice. This was associated with a remarkable amelioration of the disruption of the colonic architecture, a significant reduction in colonic myeloperoxidase (MPO) activity, and a decrease in the production of inflammatory mediators such as nitric oxide (NO), prostaglandin (PG) E2, and pro-inflammatory cytokines. In addition, chrysin inhibited tumor necrosis factor (TNF)-α-induced activation of NF-κB in IEC-6 cells. These findings suggest that chrysin exerts potentially clinically useful anti-inflammatory effects mediated through the suppression of NF-κB activation. |
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