A Phantom Bursting Mechanism for Episodic Bursting |
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Authors: | Richard Bertram Joseph Rhoads Wendy P Cimbora |
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Institution: | (1) Department of Mathematics, Florida State University, Tallahassee, FL 32306-4510, USA;(2) Programs in Neuroscience and Molecular Biophysics, Florida State University, Tallahassee, FL 32301, USA |
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Abstract: | We describe a novel dynamic mechanism for episodic or compound bursting oscillations, in which bursts of electrical impulses
are clustered together into episodes, separated by long silent phases. We demonstrate the mechanism for episodic bursting
using a minimal mathematical model for “phantom bursting.” Depending on the location in parameter space, this model can produce
fast, medium, or slow bursting, or in the present case, fast, slow, and episodic bursting. The episodic bursting is modestly
robust to noise and to parameter variation, and the effect that noise has on the episodic bursting pattern is quite different
from that of an alternate episodic burst mechanism in which the slow envelope is produced by metabolic oscillations. This
mechanism could account for episodic bursting produced in endocrine cells or neurons, such as pancreatic islets or gonadotropin
releasing neurons of the hypothalamus. |
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Keywords: | Bursting Electrical oscillations Pancreatic islets Beta-cells Endocrine cells Neurons |
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