Effect of 1-(1-Naphtylmethyl)-piperazine,an Efflux Pump Inhibitor,on Antimicrobial Drug Susceptibilities of Clinical <Emphasis Type="Italic">Acinetobacter baumannii</Emphasis> Isolates |
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Authors: | Ahmet Yilmaz Coban Akif Koray Guney Yeliz Tanriverdi Cayci Belma Durupinar |
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Institution: | (1) Medical School, Department of Microbiology and Clinical Microbiology, Ondokuz Mayis University, 55139 Samsun, Turkey |
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Abstract: | In this study, the effects of 1-(1-naphtylmethyl)-piperazine (NMP), an efflux pump inhibitor, on antimicrobial drug susceptibilities
of 42 clinical Acinetobacter baumannii isolates were investigated by the disc diffusion method. The inhibition zone diameters of antibiotic discs were tested in
the presence and absence of NMP and then these zone diameters were compared. Presence of NMP restored ciprofloxacin susceptibility
in 15 intermediate and 2 resistant isolates. One ciprofloxacin resistant isolate became intermediate in the presence of NMP.
One isolate resistant to gentamicin became intermediate with NMP. Interestingly, one isolate susceptible to meropenem became
resistant in the presence of NMP. Although NMP increased the inhibition zone diameters of some of the tested antibiotics against
the resistant isolates, the increase was not enough to restore susceptibility. In conclusion, the presence of NMP increases
the zone diameters of ciprofloxacin and levofloxacin. Intermediate strains become susceptible but the resistant isolates do
not. |
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