Circadian rhythms of adrenaline and noradrenaline excretion in man in normal conditions and after alcohol intake

Circadian rhythms of adrenaline and noradrenaline excretion with urine in health and during 3 days after a single intake of 40 degrees alcohol from 5 to 6 p.m. in a dose of 6.2 ml/kg bw were examined in 20 healthy male volunteers aged 20 to 26 years, in spring. The data obtained were processed according to the "cosinor" program. Alcohol intake resulted in the tension of the sympathoadrenal system, with that tension being observed over 2 days and not removed after ethanol elimination. Circadian rhythms of catecholamine excretion essentially changed. Within the first day after alcohol intake, mesor and rhythm amplitudes increased, acrophases displaced for a time following alcoholization. By the second day the increase of the mesors was preserved, the acrophases returned to normal. Complete recovery of the normal circadian time structure took place during the third circadian cycle after alcohol intake.