Effects of selective modulation of the central melanocortin-3-receptor on food intake and hypothalamic POMC expression |
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Authors: | Lee Michelle Kim Andrea Conwell Irene M Hruby Victor Mayorov Alexander Cai Minying Wardlaw Sharon L |
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Institution: | Department of Medicine, Columbia University College of Physicians & Surgeons, New York, NY 10032, USA. |
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Abstract: | Hypothalamic POMC neurons regulate energy balance via interactions with brain melanocortin receptors (MC-Rs). POMC neurons express the MC3-R which can function as an inhibitory autoreceptor in vitro. We now demonstrate that central activation of MC3-R with ICV infusion of the specific MC3-R agonist, D-Trp(8)]-gamma-MSH, transiently suppresses hypothalamic Pomc expression and stimulates food intake in rats. Conversely, we also show that ICV infusion of a low dose of a selective MC3-R antagonist causes a transient decrease in feeding and weight gain. These data support a functional inhibitory role for the MC3-R on POMC neurons that leads to changes in food intake. |
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