Protective effect of propionyl-L-carnitine against ischaemia and reperfusion-damage |
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Authors: | Roberto Ferrari Claudio Ceconi Salvatore Curello Evasio Pasini Odoardo Visioli |
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Institution: | (1) Cattedra di Cardiologia dell'Università di Brescia, Brescia, Italy |
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Abstract: | Summary Reperfusion of isolated rabbit heart after 60 min of ischaemia resulted in poor recovery of mechanical function, release of reduced (GSH) and oxidized glutathione (GSSG), reduction of tissue GSH/GSSG ratio and shift of cellular thiol redox state toward oxidation, suggesting the occurrence of oxidative stress. Pretreatment of the isolated heart with propionyl-L-carnitine (10–7M) improved the functional recovery of the myocardium, reduced GSH and GSSG release and attenuated the accumulation of tissue GSSG. This effect was specific for propionyl-L-carnitine as L-carnitine and propionyl acid did not modify myocardial damage. |
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Keywords: | propionyl-L-carnitine myocardial-protection post-ischaemic reperfusion oxidative damage |
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