Enantioselective esterification of ibuprofen in supercritical carbon dioxide by immobilized lipase |
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Authors: | Markku Rantakylä Olli Aaltonen |
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Affiliation: | (1) Technical Research Centre of Finland (VTT), Chemical Technology, P.O. Box 1401, FIN - 02044, VTT, Finland |
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Abstract: | The enantioselective esterification of racemic ibuprofen with n-propanol by immobilized Mucor miehel lipase in supercritical carbon dioxide was studied. The enantiomeric excess of the product (eep) was 70 % at 15...20 % conversion. The enantioselectivity was faintly affected by temperature and the concentration of ibuprofen and lipase. The optimum temperature was 45 °C. The initial reaction rate increased with pressure, but enantioselectivity was not affected by pressure changes. The reaction rates in supercritical carbon dioxide at optimized conditions and in n-hexane were similar. |
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