Phenazine-1-carboxylic acid derivatives: design, synthesis and biological evaluation against Rhizoctonia solani Kuhn |
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Authors: | Ye Long Zhang Hongyan Xu Hong Zou Qi Cheng Chao Dong Dexian Xu Yuquan Li Rongxiu |
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Institution: | Key Laboratory of MOE for Microbial metabolism and School of Life Sciences & Biotechnology, Shanghai Jiao Tong University, Shanghai, China. |
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Abstract: | Rhizoctonia solani Kuhn is the pathogen that causes sheath blight and results in significant yield reduction in rice and in nearly 50 other crops. In order to develop a new fungicide effective against this pathogen, a series of structurally diverse phenazine-1-carboxylic acid derivatives, 2a, 2b, 2c, 2d, 2e, 2f, 2g, 2h, 2i, 2j, and 2k, were designed, synthesized and evaluated for their antifungal activity. The two most active compounds 2i and 2j were selected as lead compounds for further antifungal research. |
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