Rapid changes in the exon/intron structure of a mammalian thrombin inhibitor gene |
| |
Authors: | Kamp P B Ragg H |
| |
Affiliation: | Department of Biotechnology, Faculty of Technology, University of Bielefeld, D-33501, Bielefeld, Germany. |
| |
Abstract: | The genomic organization of the heparin cofactor II (HCII) gene from rat and mouse was investigated and compared with their human counterpart. The genes share a common core structure consisting of five exons interrupted by four introns, but the mouse and rat gene reveal individual additional features. A unique differentially spliced exon is present in the 5'-untranslated region of the rat gene, which most probably has arisen de novo by point mutations in intronic sequences of the ancestor gene. In the mouse HCII gene, a novel intron/exon boundary has been created due to the presence of an additional DNA segment, which simultaneously provides a 3'-splice site and a polypyrimidine stretch leading to an alternatively used exon of increased size. Our data suggest that, in contrast to most other mammalian genes, the exon/intron pattern of the gene coding for HCII is in dynamic evolution. |
| |
Keywords: | |
本文献已被 PubMed 等数据库收录! |
|