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Oxidative metabolism of anandamide
Authors:Burstein S H  Rossetti R G  Yagen B  Zurier R B
Affiliation:Department of Biochemistry, University of Massachusetts Medical School, 55 Lake Avenue North, Worcester, MA, USA. sumner.burstein@umassmed.edu
Abstract:In addition to the well studied hydrolytic metabolism of anandamide, a number of oxidative processes are also possible. Several routes somewhat analogous to the metabolism of free arachidonic acid have been reported. These involve mediation by various lipoxygenases and COX-2 and lead to ethanolamide analogs of the prostaglandins and HETES. The physiological significance of these products is not well understood at this time. There are also preliminary data suggesting a pathway involving oxidation of the hydroxy group of anandamide to a putative metabolite, N-arachidonyl glycine (AA-gly). This molecule displays activities in experimental models that suggest that it may play a role in some of the activities attributed to its precursor, anandamide.
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