Antitumor activity of paclitaxel and epirubicin in human breast carcinoma, R-27 |
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| Authors: | F Asanuma Y Yamada E Kawamura K Lee H Kobayashi T Yamada T Suzuki T Kubota |
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| Institution: | (1) Department of Surgery, Kitasato Institute Hospital, Tokyo, Japan;(2) Department of Urology, Kitasato Institute Hospital, Tokyo, Japan;(3) Department of Gynecology, Kitasato Institute Hospital, Tokyo, Japan;(4) Biomedical Laboratory, Kitasato Institute Hospital, Tokyo, Japan;(5) Department of Surgery, Keio University School of Medicine, Tokyo, Japan |
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| Abstract: | The antitumor effect of paclitaxel, epirubicin, and both in combination was tested using R-27, an estrogen receptor-positive
human breast carcinoma. In anin vivo study using nude mice both drugs showed an additive effect, whereas they showed a supraadditive pattern inin vitro MTT assay. The combination of paclitaxel and epirubicin may enhance the antitumor effect on breast carcinoma. |
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