Functionalized thermoresponsive micelles self-assembled from biotin-PEG-b-P(NIPAAm-co-HMAAm)-b-PMMA for tumor cell target |
| |
Authors: | Cheng Cheng Wei Hua Zhu Jing-Ling Chang Cong Cheng Han Li Cao Cheng Si-Xue Zhang Xian-Zheng Zhuo Ren-Xi |
| |
Institution: | Key Laboratory of Biomedical Polymers of Ministry of Education, Department of Chemistry, Wuhan University,Wuhan 430072, China. |
| |
Abstract: | Novel micelles, comprising hydrophilic PEG shells, hydrophobic PMMA cores, and thermosensitive P(NIPAAm-co-HMAAm) segments were self-assembled from the biotin-PEG-b-P(NIPAAm-co-HMAAm)-b-PMMA triblock copolymer. The thermosensitive micelles exhibited superior stability and showed thermotriggered drug release behavior upon temperature alterations. The fluorescence spectroscopy and confocal microscopy studies confirmed that the self-assembled biotinylated micelles can be specifically and efficiently bonded to cancer cells with the administration of biotin-transferrin, suggesting that the multifunctional micelles have great potential as drug carriers for tumor targeting chemotherapy. |
| |
Keywords: | |
本文献已被 PubMed 等数据库收录! |
|