Sequence-based association analysis of HLA class I and II alleles in Japanese supports conservation of common haplotypes |
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| Authors: | K Tokunaga Yoshihide Ishikawa Atsuko Ogawa Huiru Wang Shigeki Mitsunaga Satoshi Moriyama Ling Lin Makoto Bannai Yoshihisa Watanabe Kouichi Kashiwase Hidenori Tanaka Tatsuya Akaza Kenji Tadokoro Takeo Juji |
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| Institution: | (1) Department of Human Genetics, Graduate School of International Health, University of Tokyo, Tokyo, Japan, JP;(2) Japanese Red Cross Central Blood Center, Tokyo, Japan, JP;(3) Tokyo Metropolitan Blood Center, Tokyo, Japan, JP |
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| Abstract: | Alleles of HLA-A, B, C, DRB1, DQB1, and DPB1 loci were fully determined in 117 healthy Japanese. A
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2402, A
*
3303, A
*
1101, A
*
0201, B
*
4403, B
*
5201, Cw
*
0102, Cw
*
1403, Cw
*
0304, Cw
*
0702, Cw
*
0801, and Cw
*
1202 showed frequencies of over 10%. Multi-locus haplotype frequencies were estimated by the maximum likelihood method. Strength
of association between C and B loci was comparable with that between DRB1 and DQB1 loci. Alleles unidentified by a serological method and having very similar nucleotide sequences (A2: A
*
0201, A
*
0206, A
*
0207, B61: B
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4002, B
*
4006) were carried by different haplotypes. Several frequent five-locus haplotypes were identified including A
*
3303-Cw
*
1403-B
*
4403-DRB1
*
1302-DQB1
*
0604, and A
*
2402-Cw
*
1202-B
*
5201-DRB1
*
1502-DQB1
*
0601. These sequence-based haplotypes corresponded to serology-based common haplotypes which have already been described in Japanese.
These findings indicate that common HLA haplotypes consist of particular sets of HLA alleles and that these haplotypes have been conserved through recent human evolution.
Received: 25 November 1996 / Revised: 20 January 1997 |
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