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DNA damage-induced translocation of S100A11 into the nucleus regulates cell proliferation |
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| Authors: | Theresa Gorsler Ulrike Murzik Tobias Ulbricht Julia Hentschel Peter Hemmerich Christian Melle |
| Affiliation: | 1.Core Unit Chip Application (CUCA), Institute of Human Genetics and Anthropology,University Hospital Jena,Jena,Germany;2.Department of Molecular Biology, Fritz Lipmann Institut (FLI),Leibniz Institute for Age Research,Jena,Germany;3.Abt. Molekulare Onkologie,Universit?tsmedizin G?ttingen, Georg-August-Universit?t,G?ttingen,Germany;4.Membrane Trafficking Group; Fritz Lipmann Institut (FLI),Leibniz Institute for Age Research,Jena,Germany;5.Biomolecular Photonics Group,University Hospital Jena,Jena,Germany |
| Abstract: | BackgroundProteins are able to react in response to distinct stress stimuli by alteration of their subcellular distribution. The stress-responsive protein S100A11 belongs to the family of multifunctional S100 proteins which have been implicated in several key biological processes. Previously, we have shown that S100A11 is directly involved in DNA repair processes at damaged chromatin in the nucleus. To gain further insight into the underlying mechanism subcellular trafficking of S100A11 in response to DNA damage was analyzed. |
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