Influence of aqueous extract of Hibiscus sabdariffa L. petal on cadmium toxicity in rats |
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Authors: | S O Asagba M A Adaikpoh H Kadiri F O Obi |
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Institution: | (1) Department of Biochemistry, Delta State University, P.M.B. 1, Abraka, Delta State, Nigeria;(2) Department of Biochemistry, University of Benin, P.M.B. 1154, Benin City, Edo State, Nigeria |
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Abstract: | The effects of chronic exposure to cadmium (Cd) on some selected biochemical parameters, as well as the possible protective
role of aqueous extracts of Hibiscus sabdariffa L petal were studied in 12-wk-old male Wistar albino rats. Exposure to Cd caused a significant increase in plasma l-alanine aminotransferases (ALT) only but with a corresponding decrease in liver l-alanine and l-aspartate aminotransferases (L-ALT, L-AST) when compared to the Cd-free control. Total superoxide dismutase activity was
decreased in the liver, testis, and prostate of Cd-exposed rats, whereas malondialdehyde (MDA) concentrations were increased
relative to the Cd-free control. The metal significantly increased prostatic acid phosphatase activity in the prostate, but
decreased the body weight gain of the rats and organ/body weight ratio for prostate and testis compared to the Cd-free control.
Pretreatment of rats with aqueous extract of H. sabdariffa resulted in significantly less hepatotoxicity than with Cd alone as measured by plasma ALT and liver ALT and AST activities.
The extract also protected the rats against Cd-induced liver, prostate, and testis lipoperoxidation as evidenced by significantly
reduced MDA values in these organs, as well as reduced prostatic acid phosphatase activity in the prostate, when compared
to the Cd-only exposed rats. Also, when compared to the organ/body weight ratios obtained from rats exposed to Cd alone the
prostate and testis were protected by the extract as shown by enhanced prostate/body weight and testis/body weight ratios
of Cd- and extract-treated rats. These data suggest that H. sabdarrifa L might be protective in Cd toxicity. |
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Keywords: | Cadmium Hibiscus sabdariffa hepatoprotection antioxidant enzymes phosphatase lipid peroxidation rats |
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