Biomedical applications of glyconanoparticles based on quantum dots |
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Authors: | C.R.A. Cunha A.D.P.R. Oliveira T.V.C. Firmino D.P.L.A. Tenório G. Pereira L.B. Carvalho B.S. Santos M.T.S. Correia A. Fontes |
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Affiliation: | 1. Departamento de Biofísica e Radiobiologia, Universidade Federal de Pernambuco, Recife, PE, Brazil;2. Departamento de Bioquímica e Fisiologia, Universidade Federal de Pernambuco, Recife, PE, Brazil;3. Laboratório de Imunopatologia Keizo Asami, Universidade Federal de Pernambuco, Recife, PE, Brazil;4. Departamento de Química Fundamental, Universidade Federal de Pernambuco, Recife, PE, Brazil;5. Departamento de Ciências Farmacêuticas, Universidade Federal de Pernambuco, Recife, PE, Brazil;6. Programa de Pós-Graduação em Ciências Biológicas, Universidade Federal de Pernambuco, Recife, PE, Brazil;7. Programa de Pós-Graduação em Biologia Aplicada à Saúde, Universidade Federal de Pernambuco, Recife, PE, Brazil |
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Abstract: | BackgroundQuantum dots (QDs) are outstanding nanomaterials of great interest to life sciences. Their conjugation versatility added to unique optical properties, highlight these nanocrystals as very promising fluorescent probes. Among uncountable new nanosystems, in the last years, QDs conjugated to glycans or lectins have aroused a growing attention and their application as a tool to study biological and functional properties has increased.Scope of reviewThis review describes the strategies, reported in the literature, to conjugate QDs to lectins or carbohydrates, providing valuable information for the elaboration, improvement, and application of these nanoconjugates. It also presents the main applications of these nanosystems in glycobiology, such as their potential to study microorganisms, the development of diseases such as cancer, as well as to develop biosensors.Major conclusionsThe development of glyconanoparticles based on QDs emerged in the last decade. Many works reporting the conjugation of QDs with carbohydrates and lectins have been published, using different strategies and reagents. These bioconjugates enabled studies that are very sensitive and specific, with potential to detect and elucidate the glycocode expressed in various normal or pathologic conditions.General significanceProduce a quick reference source over the main advances reached in the glyconanotechnology using QDs as fluorescent probes. |
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Keywords: | Quantum dots Lectin Carbohydrate Glycobiology Fluorescence |
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