DNA-cation interactions: The major and minor grooves are flexible ionophores. |
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| Authors: | N V Hud M Polak |
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| Affiliation: | School of Chemistry and Biochemistry, Parker H Petit Institute of Bioengineering and Biosciences, Georgia Institute of Technology, Atlanta, Georgia 30332-0400, USA. hud@chemistry.gatech.edu |
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| Abstract: | Several crystallographic, solution-state and theoretical studies carried out this past year provide new support for the sequence-specific nature of monovalent and divalent cation coordination within the DNA major and minor grooves. Correlations observed between groove width and cation coordination indicate that the grooves are flexible and respond to cation binding. |
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