Studies on deoxyribonucleic acid polymerase from normal and down’s syndrome skin fibroblasts in vitro |
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Authors: | Russell E Giblak Ernest E McCoy |
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Institution: | (1) Department of Pediatrics, Faculty of Medicine, University of Alberta, Edmonton, Alberta, Canada |
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Abstract: | Summary This investigation showed that: (a) hypotonic pH 5.0 extracts of normal and Down’s syndrome fibroblasts cells (DS) exhibit
DNase activity which appears to be very similar in nature and extent; (b) DNA polymerase activity was generally increased
in DS cells when compared with normal cells; (c) DNA polymerase activity was increased with increased passage age for both
normal and DS fibroblasts, but the normal fibroblast was never found to overlap with DS cell activity; and (d) normal cells
appear to have a similar DNA polymerase activity at all chronological ages, whereas DS cells exhibit a decrease in activity
with increased age of the donor. |
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Keywords: | |
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