Changes of cerebral gamma glutamyltransferase activities after treatment with exogenous inducers |
| |
Authors: | J. F. Ghersi-Egea A. Minn G. Siest |
| |
Affiliation: | (1) Centre du Médicament, U.A. CNRS no 597, Université de Nancy-1, 30 rue Lionnois, F-54000 Nancy, France |
| |
Abstract: | The activity of gamma-glutamyltransferase localized in isolated brain synaptic membranes- and microvessels-enriched fractions was assayed after treatment of rats with either phenobarbital or ethanol. Phenobarbital increased the activity of gamma-glutamyltransferase in microvessels, without alteration of synaptic membranes activity. An increase of enzyme activity was also obtained after a chronic intoxication with ethanol. These results suggest that the isoform of gamma-glutamyltransferase localized in brain microvessels may respond to exogenous inducers. |
| |
Keywords: | Gamma glutamyltransferase induction microvessels synaptic membrane |
本文献已被 SpringerLink 等数据库收录! |